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eIMBL Unit Labs
Faculty Members
DNA Replication
Systems Biology
Genomic Medicine
Molecular Oriental Medicine
Infectious Disease
DNA Replication
DNA replication unit lab currently consists of 13 members from Korea, Hong Kong, Italy and Japan. On July 11-13, 2005, 10 members out of these 13 gathered at the Seoul National University for the first eIMBL workshop. The members are experts on various aspects of DNA replication, an essential process for cell proliferation.
The current issues of interest on DNA replication include
1) Genome-wide distribution of replication origins and replication machinery as well as early and late replicating segments
2) Molecular basis for selection of replication origins and determination of replication timing, as well as for their plasticity
3) Assembly of initiation complexes and its activation for initiation of DNA synthesis
4) Architecture of the replication fork complex capable of efficient duplex unwinding and coordinated DNA synthesis
5) Cell cycle regulation of assembly, disassembly, degradation and activation of protein complexes required for the
processes of DNA replication which permit once and only once DNA replication during a single cell cycle
6) Cellular signal transduction pathways induced by perturbed replication forks
7) Machinery for processive DNA chain elongation and its modification during the course of fork inhibition
8) Aberration of replication machinery and its regulators in diseases and during senescence
9) Roles of replication factors in specific aspects of differentiation and development
10) Development of replication factors as novel therapeutic targets for prediction, diagnosis, treatment and prevention of
diseases.
These issues are among the central problems not only in the field of DNA replication but also in the field of cell cycle and chromosome dynamics in general, and have pertinent implication in development of various diseases. Each member has made significant contribution to some of these issues. We will facilitate the communication of the members through video conferences on the web on a regular basis as well as through the eIMBL homepage. We plan to expand the members in other regional countries and are hoping that eIMBL will help to accelerate further development of the DNA replication studies in this area by building a highly communicative and interactive research network.
